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Zhaohua Irene Tang
Associate Professor of Biology
 
Email: itang@jsd.claremont.edu
Office: Keck Science Center 201
Phone: 909-607-9067
Office Hours:
Web Site: http://faculty.jsd.claremont.edu/ztang
   
Courses Taught This Year:
Fall BIOL 043L Introductory Biology Section 3
  MWF 10:00-10:50 <> BC 25
 
   
Fall BIOL 157L Cell Biology Section 1
  MW 12:00-1:10 <> BC 23
 
   
Spring BIOL 158 Cell Cycle, Diseases & Aging Section 1
  MW 12:00-1:10 <> BC 23
 
   
Spring BIOL 177 Biochemistry Section 1
  MWF 10:00-10:50 <> BC 36
 
   
Spring CHEM 177 Biochemestry Section 1
  MWF 10:00-10:50 <> BC 36
 
   
Educational Background:
Peking University Medical School, Beijing, P. R. of China
B.S. State University of New York at Stony Brook
Ph.D. University of California, Los Angeles
Postdoctoral Fellow, California Institute of Technology, Pasadena, CA
Courses Taught:
Introductory Chemistry, lecture and lab
Introductory Biochemistry, lecture and lab
Advanced Biochemistry, lecture and lab
Physical Chemistry with Applications to Life Sciences

Regulation of the Cell-division Cycle (lecture)
Physical Chemistry for Molecular Biology Program (lecture)

Introductory Biology, lecture and lab
Cell Biology, lecture and lab
Cell Cycle, Diseases, and Aging (lecture)
Biology 177 Biochemistry (Lecture)
Research Interests:
To investigate the functions of several protein kinases in the regulation of cell cycle progression and cell death, in the response to environmental factors, as well as in the cellular sensitivity to anticancer drugs, using a single-cell eukaryotic organism, fission yeast Schizosaccharomyces pombe as an in vivo model.
Thesis Topics:
Using a single-cell eukaryotic organism, fission yeast Schizosaccharomyces pombe as an in vivo model to investigate the functions of several protein kinases in the regulation of cell-division cycle and in the cellular response to the environmental stress factors and to the anticancer drug cisplatin.
The major areas:
SR Protein-specific Kinases and SR-like Proteins in Coordinating Eukaryotic Gene Expression with Cell Cycle Transitions in Fission Yeast
Genomic Analysis of Response Pathways to Environmental Factors Using Fission Yeast as a Biological Model System
 
Selected Publications List: Click to open new window.
1.   Tang, Z., Alaei, Tsurumi, A., C., Wilson, C., S., Chiu, C., Oya, J., and Ngo, B. . (2007). Dsk1 Kinase Phosphorylates SR Proteins and Regulates Their Cellular Localization in Fission Yeast. . Biochemical Journal   405 (1): 21-30. Abstract Article
 
2.   Huang, C-J, Tang, Z, Lin, R.-J, and Tucker, P.W. . (2007). Phosphorylation by SR kinases regulates the binding of PTB-associated splicing factor (PSF) to the pre-mRNA polypyrimidine tract. . FEBS lett   581(2): 223-232. Abstract
 
3.   Tang, Z., Mandel, L., Yean, S.-L., Lin*, C.X., Chen*, T., Yanagida, M., and Lin, R.-J. . (2003). The Kic1 Kinase of Schizosaccharomyces pombe Is a CLK/STY Orthologue That Regulates Cell-Cell Separation. Experimental Cell Research   283: 101-115. Abstract Article
 
4.   Portal, D., Lobe, G.S., Kadener, S., Prasad, J., Espinosa, J.M., Pereira, C.A., Tang, Z., Lin, R.-J., Manley, J.L., Kornblihtt, A.R., Flawia M.M., and Torres H.N. . (2003). Trypanosoma cruzi TcSRPK, The First Protozoan Member of The SRPK Family, Is Biochemically and Functionally Conserved with Metazoan SR Protein-specific Kinases. Molecular and Biochemical Parasitology   127: 9-21. Abstract Article
 
5.   Portal, D., Espinosa J.M., Lobo G.S., Kadener S., Pereira C.A., De La Mata M., Tang Z., Lin R.-J., Kornblihtt A.R., Baralle F.E., Flawia M.M., and Torres H.N. . (2003). An Early Ancestor in The Evolution of Splicing: A Trypanosoma Cruzi Serine-arginine-rich Protein (TcSR) Is Functional in Cis-splicing. Molecular and Biochemical Parasitology   127: 37-46. Abstract Article
 
6.   Tang, Z., Käufer, N. F., and Lin, R.-J. . (2002). Interactions Between Two Fission Yeast SR-Related Proteins and Their Modulation by Phosphorylation. Biochemical Journal   368: 527-534. Abstract
 
7.   Tang, Z., Kuo*, T., Shen*, J., and Lin, R.-J. . (2000). Biochemical and Genetic Conservation of Fission Yeast Dsk1 and Human SRPK1.. Mol. Cell. Biol   20(3): 816-824. Abstract Article
 
8.   Tang, Z., Yanagida, M., and Lin, R.-J. . (1998). Fission Yeast Mitotic Regulator Dsk1 Is an SR Protein-Specific Kinase.. J. Biol. Chem   273: 5963-5969. Abstract Article
 
9.   Coleman, T.R., Tang, Z., and Dunphy, W.G. . (1993). Negative Regulation of the Weel Protein Kinase by Direct Action of the Nim1/Cdr1 Mitotic Inducer. Cell   72: 919-929.
 
10.   Tang, Z., Coleman, T.R., and Dunphy, W.G. . (1993). Two Distinct Mechanisms for Negative Regulation of the Wee1 Protein Kinase.. EMBO   12(9): 3427-3436. Abstract